SL 0101-1 |
| Catalog No.GC16313 |
ribosomal S6 kinase inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 77307-50-7
Sample solution is provided at 25 µL, 10mM.
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SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. Shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase[1].
References:
[1]. Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34.
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