SN-38 Glucuronide (trifluoroacetate salt) (Synonyms: SN-38G) |
| Catalog No.GC44906 |
SN-38 glucuronide is an inactive metabolite of irinotecan, which is a derivative of the alkaloid camptothecin.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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SN-38 glucuronide is an inactive metabolite of irinotecan , which is a derivative of the alkaloid camptothecin. [1] SN-38 glucuronide is formed by glucuronidation of SN-38 , the active metabolite of irinotecan, by UDP glucuronosyl transferase 1A1 (UGT1A1) and UGT1A7. It can also be formed in COS-7 cells by UGT1A1 and UGT1A10, which are both up-regulated in an irinotecan/SN-38-resistant cell line. [2]
Reference:
[1]. Mathijssen, R.H.J., van Alphen, R.J., Verweij, J., et al. Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). Clin. Cancer Res. 7(8), 2182-2194 (2001).
[2]. Oguri, T., Takahashi, T., Miyazaki, M., et al. UGT1A10 is responsible for SN-38 glucuronidation and its expression in human lung cancers. Anticancer Res. 24(5A), 2893-2896 (2004).
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