SNOG (Synonyms: S-Nitroso-L-glutathione) |
| Catalog No.GC11815 |
SNOG (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses.
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Cas No.: 57564-91-7
Sample solution is provided at 25 µL, 10mM.
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S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.[1][2][3][4]
Reference:
[1]. Radomski, M.W., Rees, D.D., Dutra, A., et al. S-Nitroso-glutathione inhibits platelet activation in vitro and in vivo. Br. J. Pharmacol. 107(3), 745-749 (1992).
[2] Butler, A.R., and Rhodes, P. Chemistry, analysis, and biological roles of S-nitrosothiols. Anal. Biochem. 249(1), 1-9 (1997).
[3]. Gasco, A., Fruttero, R., and Sorba, G. NO-donors: An emerging class of compounds in medicinal chemistry. Farmaco 51(10), 617-635 (1996).
[4]. Cook, J.A., Kim, S.Y., Teague, D., et al. Convenient colorimetric and fluorometric assays for S-nitrosothiols. Anal. Biochem. 238(2), 150-158 (1996).
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