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10-Formyltetrahydrofolate (sodium salt) (technical grade) (Synonyms: 10-CHO-FH4, 10-CHO-THF, N10-Formyltetrahydrofolate, 10-formyl H4PteGlu, 10-fTHF)

Catalog No.GC49872

El 10-formiltetrahidrofolato (sal de sodio) (grado técnico) es una forma de Ácido tetrahidrofÓlico que actÚa como donante de grupos formilo en el anabolismo.

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10-Formyltetrahydrofolate (sodium salt) (technical grade) Chemical Structure

Cas No.: 914800-65-0

Tamaño Precio Disponibilidad Cantidad
1 mg
315,00 $
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Sample solution is provided at 25 µL, 10mM.

Description of 10-Formyltetrahydrofolate (sodium salt) (technical grade)

10-Formyltetrahydrofolate is a formyl donor and cofactor, as well as a metabolite of 5,10-methylenetetrahydrofolic acid .1 It is formed from 5,10-methylenetetrahydrofolic acid by methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) in the cytosol and MTHFD2 and MTHFD2L in the mitochondria. 10-Formyltetrahydrofolate provides the formyl group for conjugation to methionine-tRNA, which is required for mitochondrial protein translation initiation, and is also involved in purine biosynthesis.2,3

1.Li, A.M., and Ye, J.Reprogramming of serine, glycine and one-carbon metabolism in cancerBiochim. Biophys. Acta Mol. Basis Dis.1866(10)165841(2020) 2.Minton, D.R., Nam, M., McLaughlin, D.J., et al.Serine catabolism by SHMT2 is required for proper mitochondrial translation initiation and maintenance of formylmethionyl-tRNAsMol. Cell69(4)610-621(2018) 3.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide biosynthesisBiochemistry(2002)

Chemical Properties of 10-Formyltetrahydrofolate (sodium salt) (technical grade)

Cas No. 914800-65-0 SDF
Sinónimos 10-CHO-FH4, 10-CHO-THF, N10-Formyltetrahydrofolate, 10-formyl H4PteGlu, 10-fTHF
Canonical SMILES O=C1C2=C(NC(N)=N1)NCC(N2)CN(C3=CC=C(C=C3)C(N[C@H](C([O-])=O)CCC([O-])=O)=O)C=O.[Na+].[Na+]
Formula C20H21N7O7 • 2Na M.Wt 517.4
Solubility Methanol: slightly soluble,Water: slightly soluble Storage -80°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 10-Formyltetrahydrofolate (sodium salt) (technical grade)

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1 mg 5 mg 10 mg
1 mM 1.9327 mL 9.6637 mL 19.3274 mL
5 mM 0.3865 mL 1.9327 mL 3.8655 mL
10 mM 0.1933 mL 0.9664 mL 1.9327 mL
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In vivo Formulation Calculator (Clear solution) of 10-Formyltetrahydrofolate (sodium salt) (technical grade)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 33 reference(s) in Google Scholar.)

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