Inicio>>Analytical Standards>>13,14-dihydro-15-keto Prostaglandin F2α-d4

13,14-dihydro-15-keto Prostaglandin F2α-d4 (Synonyms: PGFMd4)

Catalog No.GC46429

An internal standard for the quantification of 13,14dihydro15keto PGF

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13,14-dihydro-15-keto Prostaglandin F2α-d4 Chemical Structure

Cas No.: 42932-59-2

Tamaño Precio Disponibilidad Cantidad
50 μg
105,00 $
Disponible
100 μg
199,00 $
Disponible
500 μg
939,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description of 13,14-dihydro-15-keto Prostaglandin F2α-d4

13,14-dihydro-15-keto Prostaglandin F-d4 (13,14-dihydro-15-keto PGF-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGF by GC- or LC-mass spectrometry. 13,14-dihydro-15-keto PGF is the first prominent plasma metabolite of PGF in the 15-hydroxy PGDH pathway.1 Measurement of 13,14-dihydro-15-keto PGF in plasma can be used as a marker of the in vivo production of PGF.1,2,3

1.Samuelsson, B., Goldyne, M., GranstrÖm, E., et al.Prostaglandins and thromboxanesAnnu. Rev. Biochem.47997-1029(1978) 2.Del Vecchio, R.P., Maxey, K.M., and Lewis, G.S.A quantitative solid-phase enzymeimmunoassay for 13,14-dihydro-15-keto-prostaglandin F2α in plasmaProstaglandins43(4)321-330(1992) 3.Meyer, H.H.D., Eisele, K., and Osaso, J.A biotin-streptavidin amplified enzyme immunoassay for 13,14-dihydro-15-keto-PGF2αProstaglandins38(3)375-383(1989)

Chemical Properties of 13,14-dihydro-15-keto Prostaglandin F2α-d4

Cas No. 42932-59-2 SDF
Sinónimos PGFMd4
Canonical SMILES CCCCCC(CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)=O
Formula C20H30D4O5 M.Wt 358.5
Solubility DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 5 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 13,14-dihydro-15-keto Prostaglandin F2α-d4

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.7894 mL 13.947 mL 27.894 mL
5 mM 557.9 μL 2.7894 mL 5.5788 mL
10 mM 278.9 μL 1.3947 mL 2.7894 mL
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In vivo Formulation Calculator (Clear solution) of 13,14-dihydro-15-keto Prostaglandin F2α-d4

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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