2′-O-(2-Methoxyethyl)guanosine |
| Catalog No.GC61938 |
&2#8242;-O-(2-Metoxietil)guanosina (2'-O-MOE-rG), un nucleósido modificado con 2'-O-metoxietilo, se puede producir por conversión enzimática (adenosina desaminasa) a partir de 2'-O-( Ribósido de 2-metoxietil)-2,6-diaminopurina.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 473278-54-5
Sample solution is provided at 25 µL, 10mM.
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2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA[1][2].
References:
[1]. McPherson AK, et, al. An Improved Process for the Manufacture of 5′-O-(4,4′-Dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine. Org. Process Res. Dev. 2020, 24, 11, 2583-2590.
[2]. Saleh AF, et, al. 2'-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells. Toxicol Sci. 2018 May 1;163(1):70-78.
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