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2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)

Catalog No.GC46540

A purine nucleotide

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2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate) Chemical Structure

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Tamaño Precio Disponibilidad Cantidad
25 mg
94,00 $
Disponible
50 mg
170,00 $
Disponible
100 mg
320,00 $
Disponible
250 mg
659,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description of 2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)

2'-Deoxyadenosine-5'-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5'-triphosphate .1 dATP is a substrate for DNA polymerase in the synthesis of DNA.2 It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.1 dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.3,4 dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations in the gene for adenosine deaminase, the enzyme that catalyzes the deamination of adenosine and deoxyadenosine.5

1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Key steps in nucleotide biosynthesis are regulated by feedback inhibitionBiochemistry(2002) 2.Berg, J.M., Tymoczko, J.L., and Stryer, L.DNA is replicated by polymerases that take instructions from templatesBiochemistry(2002) 3.Cadwell, R.C., and Joyce, G.F.Randomization of genes by PCR mutagenesisPCR Methods Appl.2(1)28-33(1992) 4.Steffens, D.L., Jang, G.Y., Sutter, S.L., et al.An infrared fluorescent dATP for labeling DNAGenome Res.5(4)393-399(1995) 5.Flinn, A.M., and Gennery, A.R.Adenosine deaminase deficiency: A reviewOrphanet J. Rare Dis.13(1)65(2018)

Chemical Properties of 2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)

Cas No. N/A SDF
Canonical SMILES NC1=NC=NC2=C1N=CN2[C@@]3([H])C[C@H](O)[C@@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)O3.[Na+].[Na+].[Na+].O
Formula C10H13N5O12P3.3Na [XH2O] M.Wt 557.1
Solubility PBS (pH 7.2): 10 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)

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1 mg 5 mg 10 mg
1 mM 1.795 mL 8.975 mL 17.9501 mL
5 mM 0.359 mL 1.795 mL 3.59 mL
10 mM 0.1795 mL 0.8975 mL 1.795 mL
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In vivo Formulation Calculator (Clear solution) of 2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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