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5-PA-dUTP

Catalog No.GC70654

5-PA-dUTP (5-Propargylamino-dUTP) es un nucleótido modificado por C5 y puede ser incorporado en nanopartículas de ADN (DNPs) para la administración de fotosensibilizadores.

Products are for research use only. Not for human use. We do not sell to patients.

5-PA-dUTP Chemical Structure

Cas No.: 179101-49-6

Tamaño Precio Disponibilidad Cantidad
52.12mg (100 mM * 1 mL in Triethylamine)
1.665,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description of 5-PA-dUTP

5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery. 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References:
[1]. Kyoung-Ran Kim, et al.Shaping Rolling Circle Amplification Products into DNA Nanoparticles by Incorporation of Modified Nucleotides and Their Application to In Vitro and In Vivo Delivery of a Photosensitizer. Molecules. 2018 Jul 23;23(7):1833.

Chemical Properties of 5-PA-dUTP

Cas No. 179101-49-6 SDF
Formula C12H18N3O14P3 M.Wt 521.2
Solubility H2O : 125 mg/mL (239.83 mM; Need ultrasonic) Storage Solution, -20°C, 2 years
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 5-PA-dUTP

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.9186 mL 9.5932 mL 19.1865 mL
5 mM 0.3837 mL 1.9186 mL 3.8373 mL
10 mM 0.1919 mL 0.9593 mL 1.9186 mL
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In vivo Formulation Calculator (Clear solution) of 5-PA-dUTP

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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