Arctigenin |
| Catalog No.GN10063 |
Arctigenin, un compuesto natural de lignano, ha demostrado actividades anticancerígenas en el cáncer. Arctigenina exhibe potentes actividades antioxidantes, antiinflamatorias y antivirales (virus de la influenza A).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 7770-78-7
Sample solution is provided at 25 µL, 10mM.
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Arctigenin, un compuesto natural de lignano, ha demostrado actividades anticancerígenas en el cáncer. Arctigenina exhibe potentes actividades antioxidantes, antiinflamatorias y antivirales (virus de la influenza A)[3,4].
Arctigenina (40 µM; 48h) inhibió el crecimiento de células U87MG y T98G, indujo la detención del ciclo celular en la fase G0/G1 y desencadenó la apoptosis celular en células de glioma [1]. Arctigenina (10, 20, 40, 80 y 100 μmol/L; 48h) posee actividad antitumoral en células T24 de cáncer de vejiga. A nivel molecular, la arctigenina fue capaz de reducir la expresión de ciclinas D1 y fosfo-ERK1/2, pero inducir niveles de fosfo-p38 [4]. Arctigenina (0, 1.56, 12.5, 100 μM; 24h) induce la apoptosis en células de HCC a través de vías apoptóticas dependientes de mitocondrias y Fas/FasL [5].
Arctigenina (25 mg/kg; ip; dos veces al día) durante 23 días aumentó la fosforilación de AKT estimulada por insulina en el músculo gastrocnemio y el hígado, pero no en la grasa perirrenal [2]. Arctigenina (50 mg/kg/día; ip) durante 4 días confiere protección contra el daño inflamatorio y oxidativo inducido por LPS en el pulmón [6].
References:
[1]. Maimaitili A, Shu Z, Cheng X, Kaheerman K, Sikandeer A, Li W. Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells. Oncol Lett. 2017 Feb;13(2):1007-1013
[2]. Huang SL, Yu RT, Gong J, Feng Y, Dai YL, Hu F, Hu YH, Tao YD, Leng Y. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia. 2012 May;55(5):1469-81.
[3]. Hayashi K, Narutaki K, Nagaoka Y, Hayashi T, Uesato S. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biol Pharm Bull. 2010;33(7):1199-205.
[4]. Yang S, Ma J, Xiao J, Lv X, Li X, Yang H, Liu Y, Feng S, Zhang Y. Arctigenin anti-tumor activity in bladder cancer T24 cell line through induction of cell-cycle arrest and apoptosis. Anat Rec (Hoboken). 2012 Aug;295(8):1260-6.
[5]. Lu Z, Cao S, Zhou H, Hua L, Zhang S, Cao J. Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721. PLoS One. 2015 May 1;10(5):e0125727.
[6]. Zhang WZ, Jiang ZK, He BX, Liu XB. Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling. Inflammation. 2015 Aug;38(4):1406-14.
| Experimentos celulares [1]: | |
Líneas celulares | Líneas celulares de glioma humano U87MG y T98G |
Método de preparación | Las líneas celulares de glioma humano U87MG y T98G fueron tratadas con arctigenina (1-40 μM) durante 48 horas. |
Condiciones de reacción | Arctigenina (1-40 μM); 48 h |
Áreas de aplicación | La arctigenina inhibió el crecimiento de las células U87MG y T98G de manera dependiente de la dosis. |
| Experimentos con animales [2]: | |
Modelos animales | Modelo de ratones hembra ob/ob |
Método de preparación | Se administró arctigenina a ratones hembra ob/ob (25 mg/kg; ip; dos veces al día) durante 22 días. |
Forma de dosificación | Arctigenina (200 mg/kg cada 2 días); 23 días; ip. |
Áreas de aplicación | La arctigenina (25 mg/kg; ip; dos veces al día) aumentó la fosforilación de AKT estimulada por insulina en el músculo gastrocnemio y el hígado, pero no en la grasa perirrenal. |
Referencias: [1]. Maimaitili A, Shu Z, Cheng X, Kaheerman K, Sikandeer A, Li W. Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells. Oncol Lett. 2017 Feb;13(2):1007-1013. [2]. Huang SL, Yu RT, Gong J, Feng Y, Dai YL, Hu F, Hu YH, Tao YD, Leng Y. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia. 2012 May;55(5):1469-81. | |
| Cas No. | 7770-78-7 | SDF | |
| Chemical Name | (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one | ||
| Canonical SMILES | COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC | ||
| Formula | C21H24O6 | M.Wt | 372.41 |
| Solubility | ≥ 17.2mg/mL in DMSO | Storage | Desiccate at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6852 mL | 13.4261 mL | 26.8521 mL |
| 5 mM | 0.537 mL | 2.6852 mL | 5.3704 mL |
| 10 mM | 0.2685 mL | 1.3426 mL | 2.6852 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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