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BDP9066

Catalog No.GC33340

BDP9066 es un potente y selectivo inhibidor de MRCK de la cinasa de uniÓn a Cdc42 relacionada con la distrofia miotÓnica con una IC50 de 64 nM para MRCKβ en células SCC12, valores de Ki de 0,0136 nM y 0,0233 nM para determinaciones internas de MRCKα/β, respectivamente. BDP9066 tiene un efecto terapéutico sobre el cÁncer de piel al reducir la fosforilaciÓn del sustrato.

Products are for research use only. Not for human use. We do not sell to patients.

BDP9066 Chemical Structure

Cas No.: 2226507-04-4

Tamaño Precio Disponibilidad Cantidad
  5mg
135,00 $
Disponible
  10mg
225,00 $
Disponible
  25mg
495,00 $
Disponible
  50mg
855,00 $
Disponible
  100mg
1.485,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 2 publications

Product Documents

Quality Control & SDS

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Background

BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinases MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

BDP9066 shows antiproliferative effects with greatest activity in hematologic cancer cells. BDP9066 inhibits MLC phosphorylation and blocks SCC12 squamous cell carcinoma motility and invasion[1].

BDP9066 topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes[1].

[1]. Unbekandt M, et al. Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. Cancer Res. 2018 Apr 15;78(8):2096-2114.

Chemical Properties

Cas No. 2226507-04-4 SDF
Canonical SMILES C12=C(N3CCC[C@@]4(CCCCN4)C3)C=CNC1=NC=C2C5=NC=NC=C5
Formula C20H24N6 M.Wt 348.44
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.8699 mL 14.3497 mL 28.6993 mL
5 mM 0.574 mL 2.8699 mL 5.7399 mL
10 mM 0.287 mL 1.435 mL 2.8699 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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