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Lappaconite HBr

Catalog No.GC10895

anti-inflammatory effects

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Lappaconite HBr Chemical Structure

Cas No.: 97792-45-5

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5mg
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10mg
56,00 $
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50mg
191,00 $
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Lappaconite Hydrobromide (Lappaconite HBr), a kind of alkaloid isolated from Aconitum sinomontanum Nakai and has showed anti-inflammatory effects [1, 2]. Lappaconite HBr acted as an analgesic drug in China. The Aconitum sinomontanum belongs to the Ranunculaceae family and it is used widely as an antirheumatic and analgesic agent in traditional Chinese medicine [1].

In vitro: N/A

In vivo: Lappaconite Hydrobromide absorption percentage in rat stomachs after administration was 9.67%. The absorption percentages at colon, jejunum, ileum and duodenum were, 9.51%, 11.83%, 12.95%, and 19.61%, respectively. The uptake of lappaconite hydrobromide was linearly increased when the concentration was raised from 10 mg/L to 40 mg/L, whereas the absorption rate constant kept at the same level. The LD50 values are of 10.5 mg/kg (i.p. administration) and 9.9 mg/kg (i.p. administration) in mice and rat, respectively. In addition, in anesthetized rabbits injected with lappaconite up to 1 mg/kg, cardiac arrhythmia was quickly observed [3].

References:
1.  Xie FM, Wang HC, Li JH, Shu HL, Jiang JR, Chang JP, et al. Studies on the metabolism of lappaconitine in humans. Identification of the metabolites of lappaconitine in human urine by high performance liquid chromatography. Biomed Chromatogr. 1990;4(1):43-6.
2.  Guo T, Zhang Y, Zhao J, Zhu C, Feng N. Nanostructured lipid carriers for percutaneous administration of alkaloids isolated from Aconitum sinomontanum. J Nanobiotechnology. 2015;13:47.
3.  Shamma M, Chinnasamy P, Miana GA, Khan A, Bashir M, Salazar M, et al. The alkaloids of Delphinium cashmirianum. J Nat Prod. 1979;42(6):615-23.

Chemical Properties

Cas No. 97792-45-5 SDF
Chemical Name (Z)-N-(2-((((3S,6S,6aS,7S,7aS,8S,9R,10S,11aS,12S,14S)-1-ethyl-7a,11a-dihydroxy-6,8,10-trimethoxytetradecahydro-1H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-3-yl)oxy)carbonyl)phenyl)acetimidic acid hydrobromide
Canonical SMILES CCN1C[C@]2(OC(C3=CC=CC=C3/N=C(O)/C)=O)CC[C@@](OC)([H])[C@@]4([C@]5([H])C[C@]6([H])[C@](OC)([H])C[C@@]7(O)[C@@]5(O)[C@@]6([H])OC)[C@]2([H])C[C@@]7([H])C41[H].Br
Formula C32H45BrN2O8 M.Wt 665.61
Solubility DMSO : 28mg/mL Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.5024 mL 7.5119 mL 15.0238 mL
5 mM 0.3005 mL 1.5024 mL 3.0048 mL
10 mM 0.1502 mL 0.7512 mL 1.5024 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for Lappaconite HBr

Average Rating: 5 ★★★★★ (Based on Reviews and 16 reference(s) in Google Scholar.)

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