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Ciliobrevin D

Catalog No.GC39359

Ciliobrevin D es un inhibidor especÍfico, reversible y permeable a las células de la dineÍna citoplasmÁtica motora ATPasa AAA+. Ciliobrevin D inhibe la seÑalizaciÓn de Hedgehog (Hh) y la formaciÓn de cilios primarios. Ciliobrevin D inhibe el deslizamiento de microtÚbulos dependiente de dineÍna y la actividad ATPasa in vitro.

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Ciliobrevin D Chemical Structure

Cas No.: 1370554-01-0

Tamaño Precio Disponibilidad Cantidad
10mM (in 1mL DMSO)
123,00 $
Disponible
1mg
45,00 $
Disponible
5mg
112,00 $
Disponible
10mg
173,00 $
Disponible
25mg
343,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description of Ciliobrevin D

Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro[1][2].

[1]. Firestone AJ, et al. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature. 2012 Mar 18;484(7392):125-9. [2]. Miao Y, et al. Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement. Cell Cycle. 2017;16(21):2139-2145. [3]. Wen Q, et al. Dynein 1 supports spermatid transport and spermiation during spermatogenesis in the rat testis. Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E924-E948.

Chemical Properties of Ciliobrevin D

Cas No. 1370554-01-0 SDF
Canonical SMILES O=C(C1=C(C=C(Cl)C=C1)Cl)/C(C#N)=C(N2)/NC3=CC(Cl)=CC=C3C2=O
Formula C17H8Cl3N3O2 M.Wt 392.62
Solubility DMSO: 5 mg/mL (12.73 mM; ultrasonic and warming and heat to 80°C) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Ciliobrevin D

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1 mg 5 mg 10 mg
1 mM 2.547 mL 12.735 mL 25.4699 mL
5 mM 0.5094 mL 2.547 mL 5.094 mL
10 mM 0.2547 mL 1.2735 mL 2.547 mL
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In vivo Formulation Calculator (Clear solution) of Ciliobrevin D

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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