Cimpuciclib tosylate |
| Catalog No.GC65878 |
El tosilato de cimpuciclib es un inhibidor selectivo de CDK4 (IC50: 0,49 nM) que tiene actividad antitumoral.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2408872-84-2
Sample solution is provided at 25 µL, 10mM.
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Cimpuciclib tosylate is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity[1].
Cimpuciclib (example 63, 141.2 nM, 6 days) tosylate inhibits proliferation of colo205 cells[1].
Cell Proliferation Assay[1]
| Cell Line: | Colo205 cells |
| Concentration: | 0-500 nM approximately |
| Incubation Time: | 6 days |
| Result: | Inhibited cell proliferation with an IC50 value of 141.2 nM. |
Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) tosylate inhibits tumor growth in colo205 tumor-bearing mice[1].
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) tosylate shows slow metabolic rate and maintains high concentration in the plasma[1].
| Animal Model: | Colo205 tumor-bearing mice[1] |
| Dosage: | 50 mg/kg, twice a week |
| Administration: | Oral gavage |
| Result: | Inhibited tumor growth by 93.63% |
| Animal Model: | Rats, colo205 tumor-bearing mice[1] | |||||||||||||||
| Dosage: | 5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice. | |||||||||||||||
| Administration: | Oral administration | |||||||||||||||
| Result: | Pharmacokinetic profile of Cimpuciclib (example 63).
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| Cas No. | 2408872-84-2 | SDF | |
| Formula | C37H43FN8O4S | M.Wt | 714.85 |
| Solubility | DMSO : 200 mg/mL (279.78 mM; Need ultrasonic) | Storage | 4°C, away from moisture |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.3989 mL | 6.9945 mL | 13.9889 mL |
| 5 mM | 0.2798 mL | 1.3989 mL | 2.7978 mL |
| 10 mM | 0.1399 mL | 0.6994 mL | 1.3989 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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