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Linoleic Acid-d11 (Synonyms: Telfairic Acid-d11, C18:2(9Z,12Z)-d11, C18:2 n-6-d11, 9,12-Octadecadienoic Acid-d11)

Catalog No.GC45499

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Linoleic Acid-d11 Chemical Structure

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500μg
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1mg
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5mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Linoleic acid-d11 contains 11 deuterium atoms at the 14, 14', 15, 15', 16, 16', 17, 17', 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of linoleic acid by GC- or LC-mass spectrometry. Linoleic acid is a PUFA found in plant tissues and most cooking oils. Deficiencies in the essential fatty acid linoleic acid are linked to coronary heart disease, growth retardation, and allergies.1,2 Linoleic acid can be metabolized by prostaglandin H synthases (PGHS) to form 9- and 13-HODE.3 The Km is 12 μM for human PGHS-1 and 27 μM for PGHS-2.3

References
1. Hashimoto, A., Katagiri, M., Torii, S., et al. Effect of the dietary α-linolenate/linoleate balance on leukotriene production and histamine release in rats. Prostaglandins 36, 3-15 (1988).
2. Laneuville, O., Breuer, D.K., Xu, N., et al. Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z,13E/Z,15Z)-octadecatrienoic acids from α-linolenic acid. The Journal of Biological Chemisty 270, 19330-19336 (1995).
3. Soyland, E., Fund, J., Rajka, G., et al. Effect of dietary supplementation with very-long-chain n-3 fatty acids in patients with psoriasis. N. Engl. J. Med. 328, 1812-1816 (1993).

Chemical Properties

Cas No. SDF
Sinónimos Telfairic Acid-d11, C18:2(9Z,12Z)-d11, C18:2 n-6-d11, 9,12-Octadecadienoic Acid-d11
Canonical SMILES [2H]C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])([2H])/C=C\C/C=C\CCCCCCCC(O)=O
Formula C18H21D11O2 M.Wt 291.5
Solubility 0.15 M Tris-HCl pH 8.5: 1 mg/ml,DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): 100 µ g/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.4305 mL 17.1527 mL 34.3053 mL
5 mM 0.6861 mL 3.4305 mL 6.8611 mL
10 mM 0.3431 mL 1.7153 mL 3.4305 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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