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IRAK4-IN-4

Catalog No.GC38799

IRAK4-IN-4 es un inhibidor de la quinasa 4 asociada al receptor de interleucina-1 (IRAK4) extraÍdo de la patente CN107163044A, Compound15, tiene una IC50 de 2,8 nM.

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IRAK4-IN-4 Chemical Structure

Cas No.: 1850276-58-2

Tamaño Precio Disponibilidad Cantidad
1mg
90,00 $
Disponible
5mg
261,00 $
Disponible
10mg
423,00 $
Disponible
25mg
756,00 $
Disponible
50mg
1.260,00 $
Disponible
100mg
1.678,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM[1].

[1]. One class has the naphthalene second dione compounds and its derivative of protease modification activities. CN107163044A.

Chemical Properties

Cas No. 1850276-58-2 SDF
Canonical SMILES O=C(C1=C(C2=CC=CC=C2)N=C3C=C(C)C=CN31)C(C4=CC=CC=C4)=O
Formula C22H16N2O2 M.Wt 340.37
Solubility DMSO: 25 mg/mL (73.45 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.938 mL 14.6899 mL 29.3798 mL
5 mM 0.5876 mL 2.938 mL 5.876 mL
10 mM 0.2938 mL 1.469 mL 2.938 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Review for IRAK4-IN-4

Average Rating: 5 ★★★★★ (Based on Reviews and 18 reference(s) in Google Scholar.)

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