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IRAK4-IN-6

Catalog No.GC61944

IRAK4-IN-6 es un inhibidor de IRAK4 selectivo y eficaz por vÍa oral con una IC50 de 4 nM, y se dirige al linfoma difuso de células B grandes mutante MyD88 L265P.

Products are for research use only. Not for human use. We do not sell to patients.

IRAK4-IN-6 Chemical Structure

Cas No.: 2454244-02-9

Tamaño Precio Disponibilidad Cantidad
10mM (in 1mL DMSO)
499,50 $
Disponible
5 mg
450,00 $
Disponible
10 mg
765,00 $
Disponible
25 mg
1.620,00 $
Disponible
50 mg
2.700,00 $
Disponible
100 mg
4.140,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma[1].

References:
[1]. Degorce SL, et al. Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors TargetingMyD88L265P Mutant Diffuse Large B Cell Lymphoma. J Med Chem. 2019 Nov 1.

Chemical Properties

Cas No. 2454244-02-9 SDF
Canonical SMILES O=C(N1CCN([C@@H]2CC[C@@H](NC3=C4C(C=CC(CC#N)=N4)=NC(NC5=CN(C)N=C5)=N3)CC2)CC1)OC
Formula C25H32N10O2 M.Wt 504.59
Solubility DMSO : 125 mg/mL (247.73 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.9818 mL 9.909 mL 19.8181 mL
5 mM 0.3964 mL 1.9818 mL 3.9636 mL
10 mM 0.1982 mL 0.9909 mL 1.9818 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for IRAK4-IN-6

Average Rating: 5 ★★★★★ (Based on Reviews and 19 reference(s) in Google Scholar.)

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