Isogarcinol (Synonyms: Cambogin) |
| Catalog No.GC40901 |
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia.
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Cas No.: 71117-97-0
Sample solution is provided at 25 µL, 10mM.
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Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 µM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis. Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 µg/ml, respectively) through cell cycle arrest and apoptosis.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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