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(R)-(+)-O-Demethylbuchenavianine

Catalog No.GC74261

(R)-(+)-O-Demethylbuchenavianine es un inhibide las cinasas dependientes de ciclina CDK.

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(R)-(+)-O-Demethylbuchenavianine Chemical Structure

Cas No.: 1364123-68-1

Tamaño Precio Disponibilidad Cantidad
1 mg
1.422,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description of (R)-(+)-O-Demethylbuchenavianine

(R)-(+)-O-Demetlbuchenavianine is an inhibitor for Cyclin-dependent kinases (CDK). (R)-(+)-O-Demetlbuchenavianine inhibits CDK1, CDK5, glycogen synthase kinase-3 (GSK3), cdc2-like kinase (CLK1) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), with IC50s of 1.1, 0.95, >10, >10 and >10 μM, respectively.

References:
[1]. Nguyen TB, et al., Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases. J Med Chem. 2012 Mar 22;55(6):2811-9.

Chemical Properties of (R)-(+)-O-Demethylbuchenavianine

Cas No. 1364123-68-1 SDF
Formula C21H21NO4 M.Wt 351.4
Solubility Storage 4°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (R)-(+)-O-Demethylbuchenavianine

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1 mg 5 mg 10 mg
1 mM 2.8458 mL 14.2288 mL 28.4576 mL
5 mM 0.5692 mL 2.8458 mL 5.6915 mL
10 mM 0.2846 mL 1.4229 mL 2.8458 mL
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In vivo Formulation Calculator (Clear solution) of (R)-(+)-O-Demethylbuchenavianine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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