PKD

Protein kinase D (PKD) are a family of serine/threonine kinases comprised of three different but closely related members of Calmodulin-dependent protein kinases, including PKD1, PKD2 and PKD3, that are involved in fission of vesicles at the Golgi compartment, coordination of cell migration and invasion, and regulation of gene transcription. All PKD protein kinases are diacylglycerol (DAG) receptors characterized by the presence of a highly conserved N-terminal regulatory domain, which consists of two zinc finger-like cysteine-rich domains, and an autoinhibitory pleckstrin homology (PH) domain. DAG is able to bind to the cysteine-rich domain of PKD enzymes, which is crucial for kinase activation.

Products for PKD

Cat.No. Nombre del producto Información
GC68537 3-IN-PP1
3-IN-PP1 es un inhibidor de la proteína quinasa D (PKD). 3-IN-PP1 tiene una amplia actividad inhibitoria sobre PKD1, PKD2 y PKD3, con valores de IC50 de 108, 94 y 108 nM respectivamente. También es un agente antitumoral de amplio espectro que inhibe el crecimiento de varias células tumorales. 3-IN-PP1 se puede utilizar en investigaciones sobre cáncer.
GC13589 CID 755673 CID 755673 es un potente inhibidor de PKD con IC50 de 182 nM, 280 nM y 227 nM para PKD1, PKD2 y PKD3, respectivamente.
GC43326 CRT0066101 (hydrochloride) Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.
GC35750 CRT0066101 dihydrochloride El diclorhidrato de CRT0066101 es un inhibidor de PKD potente y especÍfico con valores IC50 de 1, 2,5 y 2 nM para PKD1, 2 y 3 respectivamente.
GC14355 CRT5

CRT0066051
CRT5, una pirazina benzamida, es un inhibidor potente y selectivo de las tres isoformas de PKD en células endoteliales tratadas con VEGF (IC50 = 1, 2 y 1,5 nM para PKD1, PKD2 y PKD3, respectivamente).
GC11319 kb NB 142-70 A selective PKD inhibitor