Cardiovascular
Cardiovascular
The cardiovascular system consists of the heart, blood and blood vessels. These organs form the 3 major closed circulation systems in the body, i.e., the pulmonary, coronary and systemic circulations. Cardiovascular disease includes heart disease, vascular diseases of the brain and kidney, and peripheral arterial diseases. Cardiovascular disease is the leading cause of death globally. Studies on cardiovascular regulation are important to provide a better understanding of this group of diseases and to help improve the corresponding treatment.
Targets for Cardiovascular
Products for Cardiovascular
- Cat.No. Nombre del producto Información
- GC45208 α-hydroxy Metoprolol α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol.
- GC48283 α-Linolenic Acid-d14 An internal standard for the quantification of αLinolenic acid
- GC45602 α-Linolenic Acid-d5 MaxSpec• Standard
- GC49467 β-Aescin A triterpenoid saponin with diverse biological activities
- GC49890 β-Glycerophosphate-d5 (sodium salt hydrate) An internal standard for the quantification of β-glycerophosphate
- GC40105 βARK1 Inhibitor βInhibidor de ARK1 (5-[2-(5-nitro-2-furil)vinil]-2-furoato de metilo) es un inhibidor de GRK2 (β-ARK1).
- GC52400 γ-Glu-Ala (trifluoroacetate salt) A dipeptide
- GC52404 γ-Glu-Phe (trifluoroacetate salt) A dipeptide with metabolism-altering activity
- GC41393 ω-3 Arachidonic Acid methyl ester ω-3 Fatty acids, represented primarily by docosahexaenoic acid, eicosapentaenoic acid, and α-linoleate, are essential dietary nutrients required for normal growth and development.
- GC41661 (±)-4-hydroxy Propranolol β-D-Glucuronide (±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol.
- GC46273 (±)-Atenolol-d7 An internal standard for the quantification of (±)-atenolol
- GC46289 (±)-Felodipine-d5 An internal standard for the quantification of (±)-felodipine
- GC46307 (±)-Propranolol-d7 An internal standard for the quantification of propranolol
- GC40229 (±)-Warfarin-d5 (±)-Warfarin-d5 is intended for use as an internal standard for the quantification of warfarin by GC- or LC-MS.
- GC40386 (±)11(12)-EpETE Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms.
- GC40467 (±)11-HETE (±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid.
- GC41649 (±)13-HODE cholesteryl ester (±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.
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GC40430
(±)14(15)-EET
(±)14(15)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450.
- GC41651 (±)14(15)-EET-SI Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes.
- GC40434 (±)16-HETE Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.
- GC41288 (±)17(18)-EpETE-Ethanolamide (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide.
- GC40362 (±)18-HEPE (±)18-HEPE is produced by non-enzymatic oxidation of EPA.
- GC40436 (±)18-HETE (±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid.
- GC41655 (±)19(20)-EDP Ethanolamide (±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively).
- GC40437 (±)5(6)-DiHET lactone 5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET.
- GC40438 (±)5(6)-EET 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.
- GC40421 (±)8(9)-EE-14(Z)-E (±)14(15)-EE-8(Z)-E is a potent vasodilator in bovine coronary arteries.
- GC40443 (±)9-HETE (±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid.
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GC40541
(±)9-HODE
(±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid.
- GC41666 (±)9-HODE cholesteryl ester (±)9-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.
- GC40356 (±)9-HpODE (±)9-HpODE es un hidroperóxido lipídico de cadena larga, es un producto de la peroxidación del ácido linoleico.
- GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin
- GC41694 (3S)-hydroxy Quinidine (3S)-hydroxy Quinidine is an active quinidine metabolite.
- GC48508 (4-Carboxybutyl-d4)triphenylphosphonium (bromide) An internal standard for the quantification of (4-carboxybutyl)triphenylphosphonium
- GC40444 (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic Acid (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE, a major arachidonic acid metabolite from the 15-lipoxygenase pathway.
- GC49003 (E)-Ajoene A disulfide with diverse biological activities
- GC46336 (E)-Guggulsterone (E)-Guggulsterone es el metabolito de Z-guggulsterone.
- GC40552 (R)-Acenocoumarol Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase.
- GC41722 (R,S)-Carvedilol Glucuronide (R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide.
- GC40553 (S)-Acenocoumarol Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase.
- GC48719 (S)-Canadine La (S)-canadina es un alcaloide e intermedio en la biosÍntesis de la berberina con actividad insecticida.
- GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog
- GC41837 1,3,7-Trimethyluric Acid El Ácido 1,3,7-trimetilÚrico es el metabolito de la cafeÍna. La proporciÓn metabÓlica de Ácido 1,3,7-trimetilÚrico a cafeÍna se puede evaluar como biomarcador para describir la variabilidad en la actividad de CYP3A en una cohorte.
- GC46387 1,3,7-Trimethyluric Acid-d9 An internal standard for the quantification of 1,3,7-trimethyluric acid
- GC41846 1,3-Dioctanoyl-2-Oleoyl-rac-glycerol 1,3-Dioctanoyl-2-oleoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1 and sn-3 positions and oleic acid at the sn-2 position.
- GC49346 1-(3-Chlorophenyl)biguanide (hydrochloride) A 5-HT3 receptor agonist
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GC18235
1-O-Hexadecyl-sn-glycerol
1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether.
- GC42008 1-Octadecyl Lysophosphatidic Acid 1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position.
- GC49071 1-Palmitoyl-d9 Lysophosphatidic Acid An internal standard for the quantification of 1-palmitoyl lysophosphatidic acid
- GC46496 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-PC An internal standard for the quantification of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC
- GC49733 1-Stearoyl-2-eicosapentaenoyl-sn-glycero-3-PC A phospholipid
- GC49118 10-hydroxy Warfarin A metabolite of (R)-warfarin
- GC46408 11-dehydro Thromboxane B2-d4 An internal standard for the quantification of 11dehydro thromboxane B2
- GC18634 11-deoxy Prostaglandin E1 11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1.
- GC41401 11-deoxy Prostaglandin F1α 11-deoxy PGF1α is a synthetic analog of PGF1α.
- GC41402 11-deoxy Prostaglandin F1β 11-deoxy PGF1β is a synthetic analog of PGF1β.
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GC18637
11β-Prostaglandin F2α
11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.
- GC41882 12(S)-HETrE 12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA).
- GC41893 13(R)-HODE cholesteryl ester 13(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.
- GC41895 13(S)-HODE cholesteryl ester 13(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.
- GC41897 13(S)-HOTrE 13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid.
- GC40745 13,14-dehydro-15-cyclohexyl Carbaprostacyclin 13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2.
- GC41433 13,14-dihydro Prostaglandin E1 13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound.
- GC40424 14,15-EE-5(Z)-E Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.
- GC40425 14,15-EE-8(Z)-E Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.
- GC46438 14S(15R)-EET A cytochrome P450 metabolite of arachidonic acid
- GC41173 15(R)-Pinane Thromboxane A2 15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2.
- GC41166 15(S)-15-methyl Prostaglandin D2 15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2.
- GC41103 15-keto Prostaglandin A1 Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen.
- GC41935 15-keto Treprostinil (sodium salt) 15-keto Treprostinil is an impurity found in treprostinil, which is a stable analog of prostaglandin I2 with a longer plasma half-life.
- GC40973 16(R)-Iloprost Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.
- GC40974 16(S)-Iloprost Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.
- GC41159 16,16-dimethyl Prostaglandin D2 16,16-dimethyl PGD2 is a metabolically stable synthetic analog of PGD2.
- GC18777 16,16-dimethyl Prostaglandin E1 16,16-dimethyl PGE1 is a metabolically stable synthetic analog of PGE1.
- GC46464 17R(18S)-EpETE An EPA metabolite and activator of BKCa channels
- GC46474 18-Deoxyherboxidiene El 18-desoxiherboxidieno (RQN-18690A) es un potente inhibidor de la angiogénesis.
- GC18635 18-hydroxy-11-deoxy Corticosterone 18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland.
- GC40457 19(R)-HETE 19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II.
- GC40417 19-hydroxy Cholesterol 19-hydroxy Cholesterol is formed during metabolic oxidation of cholesterol.
- GC46475 19R(20S)-EpDPA A DHA metabolite
- GC18748 1a,1b-dihomo Prostaglandin E1 Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.
- GC52122 2’-Deoxyadenosine-5’-diphosphate (sodium salt) A nucleotide diphosphate
- GC42065 2,3-dinor Thromboxane B1 Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.
- GC49671 2,3-Oxidosqualene An intermediate in the biosynthesis of sterols
- GC19560 2-(2-Phenylethyl)chromone La 2-(2-feniletil)cromona (Flidersiachromone) es una de las 2-(2-feniletil)cromonas que se pueden encontrar en la madera de Águila china de Aquilaria sinensis.
- GC42135 2-chloro Palmitic Acid El Ácido 2-cloro palmÍtico, un mediador de lÍpidos inflamatorios, interfiere con la palmitoilaciÓn de proteÍnas, induce marcadores de estrés en el RE, reduce el contenido de ATP en el RE y activa la transcripciÓn y secreciÓn de IL-6, asÍ como IL-8.2-El Ácido cloro palmÍtico interrumpe la mitocondria potencial de membrana e induce la escisiÓn de procaspasa-3 y PARP. El Ácido 2-cloro palmÍtico puede atravesar la barrera hematoencefÁlica (BBB) y compromete las funciones ER y mitocondriales en la lÍnea de células endoteliales del cerebro humano hCMEC/D3.
- GC40503 2-HOBA 2-HOBA (2-HOBA), un eliminador selectivo de dicarbonilo, es un antioxidante y eliminador de radicales libres e isolevuglandinas (IsoLG).
- GC42189 2-oxo Clopidogrel 2-oxo Clopidogrel is an intermediary metabolite of clopidogrel.
- GC41104 20-carboxy Arachidonic Acid 20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures.
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GC41614
24-dehydro Cholesterol
El 24-deshidrocolesterol es una molécula similar al colesterol.
- GC46243 24-dehydro Cholesterol-d6 An internal standard for the quantification of 24-dehydro cholesterol
- GC46528 25-hydroxy Cholesterol-d6 An internal standard for the quantification of 25hydroxy cholesterol
- GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate A metabolite of certain phenols and glycosides
- GC40799 3-hydroxy-3-Methylglutaric anhydride The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase mediates the rate-limiting step in cholesterol synthesis, converting HMG-CoA to mevalonate.
- GC52048 3-hydroxy-4-Methoxyphenethylamine (hydrochloride) La 3-hidroxi-4-metoxifenetilamina (clorhidrato) es un compuesto de catecolamina que tiene un efecto inhibidor sobre la dihidropteridina reductasa.
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GC52149
306-O12B
Un lípido catiónico ionizable.
- GC42338 4-Aminobenzoic Acid hydrazide La hidrazida del Ácido 4-aminobenzoico es un inhibidor irreversible de la mieloperoxidasa MPO con una IC50 de 0,3 μM.
- GC42405 4-hydroxy Atorvastatin (calcium salt) 4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
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GC18425
4-hydroxy Atorvastatin lactone
4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
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GC42411
4-hydroxy Nonenal Alkyne
4-hydroxy Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid.