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Inicio >> Signaling Pathways >> Immunology/Inflammation >> CD73

CD73

CD73 (Ecto-5′-nucleotidase), a component of the purinergic signaling pathway, is a 70-kD glycosylphosphatidylinositol-anchored cell surface protein encoded by the NT5E gene.

CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 catalyzes the hydrolysis of AMP into adenosine and phosphate, and CD73-generated adenosine plays an important role in tumor immunoescape. CD73 plays a crucial role in switching on adenosinergic signaling. CD73 also functions as a signal and adhesive molecule that can regulate cell interaction with extracellular matrix components, such as laminin and fibronectin, to mediate the invasive and metastatic properties of cancers. Both the enzymatic and non-enzymatic functions of CD73 are involved in cancer-associated processes and are not completely independent of each other.

Overexpression of CD73 is associated with resistance to antitumor agents. Knockdown of CD73 inhibits in vitro cell growth, cell cycle progression and cell migration in many cancers. CD73 and its associated pathways may be useful as therapeutic targets.

Targets for  CD73

Products for  CD73

  1. Cat.No. Nombre del producto Información
  2. GC65293 AB-680 AB-680 es un inhibidor altamente potente, reversible y selectivo de CD73 (una ectonucleotidasa), con una Ki de 4,9 pM para hCD73, muestra una selectividad >10 000 veces sobre las ectonucleotidasas relacionadas CD39. Actividad antitumoral. AB-680 Chemical Structure
  3. GC31914 CD73-IN-1 CD73-IN-1 es un inhibidor de CD73 que se puede utilizar en el tratamiento del cÁncer extraÍdo de la patente WO 2017153952 A1, ejemplo 80. CD73-IN-1 Chemical Structure
  4. GC62331 CD73-IN-3 CD73-IN-3 es un potente inhibidor de CD73 (IC50 = 7,3 nM en el ensayo de células humanas Calu6). CD73-IN-3, ejemplo 2 extraÍdo de la patente WO2019168744 A1, tiene potencial para la investigaciÓn del cÁncer. CD73-IN-3 Chemical Structure
  5. GC62452 CD73-IN-4 CD73-IN-4 es un inhibidor potente y selectivo del Ácido metilenfosfÓnico CD73, con una IC50 de 2,6 nM para CD73 humano. CD73-IN-4 Chemical Structure
  6. GC68386 CD73-IN-5 CD73-IN-5 Chemical Structure
  7. GC36587 MethADP MethADP es un inhibidor especÍfico de CD73. MethADP Chemical Structure
  8. GC36588 MethADP sodium salt MetADP (sal de sodio) es un inhibidor especÍfico de CD73. MethADP sodium salt Chemical Structure
  9. GC69453 MethADP triammonium

    Adenosine 5'-(α,β-methylene)diphosphate triammonium

    MethADP (triamonio de adenosina 5'-alfa,beta-metilendifosfato) es un inhibidor de CD73. MethADP se puede utilizar en la investigación de la vía ATP-adenosina.

     MethADP triammonium Chemical Structure
  10. GC68344 Mupadolimab

    CPI-006

     Mupadolimab Chemical Structure
  11. GC65470 Oleclumab Oleclumab (MEDI9447) es un anticuerpo monoclonal IgG1Λ anti-CD73 humano que inhibe la funciÓn de CD73. Oleclumab tiene actividad antitumoral. Oleclumab Chemical Structure
  12. GC62694 OP-5244 OP-5244 es un inhibidor potente y activo por vÍa oral de CD73, con una IC50 de 0,25 nM. OP-5244 Chemical Structure
  13. GC62695 OP-5244 sodium El sodio OP-5244 es un inhibidor potente y activo por vÍa oral de CD73, con una IC50 de 0,25 nM. OP-5244 sodium Chemical Structure
  14. GC32795 PSB-12379 PSB-12379, un anÁlogo de nucleÓtido, es un potente inhibidor de ecto-5'-nucleotidasa (CD73) con Kis de 9,03 nM (rata) y 2,21 nM (humano). PSB-12379 Chemical Structure
  15. GC68346 Uliledlimab

    TJ004309

     Uliledlimab Chemical Structure

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