SPDP (SPDP Crosslinker) |
| Catalog No.GC30018 |
SPDP (SPDP Crosslinker) (SPDP (SPDP Crosslinker) Crosslinker) es un reticulador de cadena corta para la conjugaciÓn de amina a sulfhidrilo a través de grupos reactivos NHS-éster y piridilditiol que forman enlaces disulfuro escindibles (reducibles) con sulfhidrilos de cisteÍna. Es un enlazador ADC escindible con glutatiÓn que se utiliza para los conjugados anticuerpo-fÁrmaco (ADC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 68181-17-9
Sample solution is provided at 25 µL, 10mM.
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SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .
[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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