TCPOBOP |
| Catalog No.GC10567 |
TCPOBOP es un agonista constitutivo del receptor de androstano (CAR) que induce una fuerte proliferaciÓn de hepatocitos y hepatomegalia sin daÑo hepÁtico ni pérdida de tejido. TCPOBOP atenÚa la lesiÓn hepÁtica murina inducida por Fas al alterar las proteÍnas Bcl-2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 76150-91-9
Sample solution is provided at 25 µL, 10mM.
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TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].
TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1].
References:
[1]. Bhushan B, et al. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69(4):1702-1718.
[2]. Baskin-Bey ES, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul;44(1):252-62.
| Cas No. | 76150-91-9 | SDF | |
| Chemical Name | 1,4-bis((3,5-dichloropyridin-2-yl)oxy)benzene | ||
| Canonical SMILES | ClC1=CC(Cl)=CN=C1OC(C=C2)=CC=C2OC(C(Cl)=C3)=NC=C3Cl | ||
| Formula | C16H8Cl4N2O2 | M.Wt | 402.06 |
| Solubility | DMF: 3 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.4872 mL | 12.436 mL | 24.8719 mL |
| 5 mM | 0.4974 mL | 2.4872 mL | 4.9744 mL |
| 10 mM | 0.2487 mL | 1.2436 mL | 2.4872 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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