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XMD8-87 (Synonyms: ACK1-B19)

Catalog No.GC19387

XMD8-87 es un potente inhibidor de TNK2 con valores IC50 de 38 y 113 nM para las mutaciones D163E y R806Q, respectivamente.

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XMD8-87 Chemical Structure

Cas No.: 1234480-46-6

Tamaño Precio Disponibilidad Cantidad
5mg
74,00 $
Disponible
10mg
131,00 $
Disponible
25mg
265,00 $
Disponible
50mg
455,00 $
Disponible
100mg
803,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively.

XMD8-87 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD8-87 has IC50s of 38 nM and 113 nM for the D163E and R806Q mutations. The effects of XMD8-87 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD8-87[1].

References:
[1]. Maxson JE, et al. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.

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