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sPLA2 Inhibitor (Synonyms: KH064, Secretory Phospholipase A2 Inhibitor)

Catalog No.GC44943

sPLA2 Inhibitor, a D-tyrosine derivative, is an orally active, potent secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 29 nM for human nonpancreatic secretory PLA2 isoform IIa (hnpsPLA2-IIa).

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sPLA2 Inhibitor Chemical Structure

Cas No.: 393569-31-8

Size Price Stock Qty
500μg
$60.00
In stock
1mg
$103.00
In stock
5mg
$419.00
In stock
10mg
$756.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Secreted phospholipases A2 (sPLA2s) are a diverse family of low molecular weight PLA2s with tissue-specific expression patterns and actions. The group IIA sPLA2 (sPLA2-IIA) was originally purified from platelets and exudates from patients with rheumatoid arthritis. Its expression can be induced by inflammatory mediators, and mouse studies suggest that it may play roles in colorectal polyposis, atherosclerosis, and bacterial infections. sPLA2 inhibitor is an orally active inhibitor of sPLA2-IIA. It protects against intestinal reperfusion injury in rats when given at 10 mg/kg orally. sPLA2 inhibitor also attenuates NF-κB signaling in lung cancer cells and protects against diet-induced metabolic syndrome in rats.

Chemical Properties

Cas No. 393569-31-8 SDF
Synonyms KH064, Secretory Phospholipase A2 Inhibitor
Canonical SMILES O=C(CCCCCCC1=CC=CC=C1)N[C@@H](CCC(O)=O)CC(C=C2)=CC=C2OCC3=CC=CC=C3
Formula C31H37NO4 M.Wt 487.6
Solubility DMF: 5 mg/ml,DMSO: 2 mg/ml,Ethanol: 5 mg/ml,Ethanol:PBS (pH 7.2) (1:6): 0.1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.0509 mL 10.2543 mL 20.5086 mL
5 mM 0.4102 mL 2.0509 mL 4.1017 mL
10 mM 0.2051 mL 1.0254 mL 2.0509 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 7 reference(s) in Google Scholar.)

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