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SRS16-86

Catalog No.GC44947

A ferroptosis inhibitor

Products are for research use only. Not for human use. We do not sell to patients.

SRS16-86 Chemical Structure

Cas No.: 1793052-96-6

Size Price Stock Qty
500μg
$13.00
In stock
1mg
$24.00
In stock
5mg
$81.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Product Documents

Quality Control & SDS

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Background

SRS16-86 is an inhibitor of ferroptosis.[1] It inhibits ferroptosis induced by erastin in HT-1080 and NIH3T3 cells when used at a concentration of 1 μM. SRS16-86 (2 mg/kg) prevents renal tubular damage and increases in serum levels of urea and creatine in a mouse model of renal ischemia-reperfusion injury (IRI). In a rat model of spinal cord injury, SRS16-86 (15 mg/kg) increases the levels of glutathione peroxidase 4 (GPX4), system xc-cystine-glutamate transporter (xCT), and glutathione (GSH) and decreases levels of IL-1β, TNF-α, ICAM-1, and the lipid peroxidation marker 4-hydroxy nonenal (4HNE) in injured spinal cord epicenters.[2] It also increases tissue sparing and improves locomotor recovery in the same model.

Reference:
1. Linkermann, A., Skouta, R., Himmerkus, N., et al. Synchronized renal tubular cell death involves ferroptosis. Proc. Natl. Acad. Sci. U.S.A. 111(47), 16836-16841 (2014).
2. Zhang, Y., Sun, C., Zhao, C., et al. Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury. Brain Res. 1706, 48-57 (2019).

Chemical Properties

Cas No. 1793052-96-6 SDF
Chemical Name 3-[(Z)-(5-pyrimidinylmethylene)amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-benzoic acid, 1,1-dimethylethyl ester
Canonical SMILES O=C(OC(C)(C)C)C1=CC=C(NC23C[C@H]4C[C@H](C[C@H](C4)C3)C2)C(/N=C\C5=CN=CN=C5)=C1
Formula C26H32N4O2 M.Wt 432.6
Solubility 25mg/ml soluble in organic solvent chloroform, slight in ethanol & DMSO Storage 4°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3116 mL 11.558 mL 23.116 mL
5 mM 0.4623 mL 2.3116 mL 4.6232 mL
10 mM 0.2312 mL 1.1558 mL 2.3116 mL
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 24 reference(s) in Google Scholar.)

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