Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt) (Synonyms: Suc-LLVY-AMC) |
| Catalog No.GC52447 |
A fluorogenic substrate for the 20S proteasome and calpains
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic substrate for the 20S proteasome, other chymotrypsin-like proteases, and calpains.1,2 Upon enzymatic cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify protease activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
1.Geier, E., Pfeifer, G., Wilm, M., et al.A giant protease with potential to substitute for some functions of the proteasomeScience283(5404)978-981(1999) 2.Sasaki, T., Kikuchi, T., Yumoto, N., et al.Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substratesJ. Biol. Chem.259(20)12489-12494(1984)
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