Sulfosuccinimidyl Oleate (sodium salt) (Synonyms: SSO)

Sulfosuccinimidyl oleate (SSO) is an irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 µM to adipocytes.[1],[2] It reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin secretion.[3] SSO impairs saturated fatty acid-induced lipid accumulation and inflammation in RAW 264.7 macrophages.[4]

Reference:
[1]. Harmon, C.M., Luce, P., Beth, A.H., et al. Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: Inhibition of fatty acid transport. J.Membrane Biol. 121, 261-268 (1991).
[2]. Abumrad, N.A., el-Maghrabi, M.R., Amri, E.Z., et al. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. The Journal of Biological Chemisty 268(24), 17665-17668 (1993).
[3]. Noushmehr, H., D'Amico, E., Farilla, L., et al. Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic β-cells and mediates fatty acid effects on insulin secretion. Diabetes 54(2), 472-481 (2005).
[4]. Nicholls, H.T., Kowalski, G., Kennedy, D.J., et al. Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. Diabetes 60(4), 1100-1110 (2011).