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survivin (baculoviral IAP repeat-containing protein 5) (21-28) (Synonyms: H2N-Thr-Phe-Lys-Asn-Trp-Pro-Phe-Leu-OH )

Catalog No.GP10034

Cancer Biology Peptides

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survivin (baculoviral IAP repeat-containing protein 5) (21-28) Chemical Structure

Size Price Stock Qty
1mg
$37.00
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5mg
$107.00
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10mg
$178.00
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25mg
$253.00
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Sample solution is provided at 25 µL, 10mM.

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Background

Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibition of apoptosis and mitosis regulation1. Survivin is one of the most uniformly up-regulated genes in tumor tissues compared with healthy tissues2. High survivin expression in the primary tumor is almost invariably associated with poor patient prognosis in many cancer types. Survivin relates to poor disease outcome in a variety of tumors, i.e., neuroblastoma3, colorectal cancer4, non-small-cell lung cancers5, B-cell lymphoma6, T-cell leukemia7, hepatocellular carcinoma, esophageal carcinoma, rectal cancer, glioma, bladder cancer, soft tissue sarcoma and astrocytic tumors.

Survivin mRNA, as measured by quantitative RT-PCR in the primary tumor, has strong and independent prognostic value in human breast cancer. Survivin mRNA concentrations in the tumor can be used to classify breast cancer patients into different risk groups. 8 Cells that are unresponsive to apoptotic triggers will also be more resistant to cytotoxic treatments, as are cells that overexpress survivin9.

References:
1.Altieri DC. Validating survivin as a cancer therapeutic target. Nat Rev Cancer 2003; 3:46 -54.
2.Velculescu VE, Madden SL, Zhang L, Lash AE, Yu J, Rago C, et al. Analysis of human transcriptomes. Nat Genet 1999; 23:387-8.
3.Adida C, Berrebi D, Peuchmaur M, Reyes-Mugica M, Altieri DC. Anti-apoptosis gene, survivin, and prognosis of neuroblastoma. Lancet 1998; 351:882-3.
4.Kawasaki H, Altieri DC, Lu CD, Toyoda M, Tenjo T, Tanigawa N. Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer. Cancer Res 1998; 58:5071-4.
5.Monzo M, Rosell R, Felip E, Astudillo J, Sanchez JJ, Maestre J, et al. A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers. J Clin Oncol 1999; 17:2100 -4.
6.Adida C, Haioun C, Gaulard P, Lepage E, Morel P, Briere J, et al. Prognostic significance of survivin expression in diffuse large B-cell lymphomas. Blood 2000; 96:1921-5.
7.Nakayama K, Kamihira S. Survivin an important determinant for prognosis in adult T-cell leukemia: a novel biomarker in practical hemato-oncology. Leuk Lymphoma 2002; 43:2249 -55.
8.Paul N. Span, Fred C.G.J. Sweep et al. Survivin Is an Independent Prognostic Marker for Risk Stratification of Breast Cancer Patients. Clinical Chemistry 50:11; 1986 -1993 (2004)
9.Zaffaroni N, Daidone MG. Survivin expression and resistance to anticancer treatments: perspectives for new therapeutic interventions. Drug Resist Updat 2002; 5:65-72.

Chemical Properties

Cas No. SDF
Synonyms H2N-Thr-Phe-Lys-Asn-Trp-Pro-Phe-Leu-OH
Canonical SMILES NC(C(C)O)C(NC(CC1=CC=CC=C1)C(NC(CCCCN)C(NC(CC(N)=O)C(NC(CC2=CNC3=C2C=CC=C3)C(N4C(C(NC(CC5=CC=CC=C5)C(NC(CC(C)C)C(O)=O)=O)=O)CCC4)=O)=O)=O)=O)=O
Formula C54H73N11O11 M.Wt 1052.22
Solubility ≥105.2mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.9504 mL 4.7519 mL 9.5037 mL
5 mM 0.1901 mL 0.9504 mL 1.9007 mL
10 mM 0.095 mL 0.4752 mL 0.9504 mL
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