Home>>SW203668 (trifluoroacetate salt)
SW203668 (trifluoroacetate salt) Catalog No.GC44975

Size Price Stock Qty
1mg
$44.00
In stock
5mg
$142.00
In stock
10mg
$263.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

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Chemical Properties

Cas No. 2117405-48-6 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES COC1=CC=C2C(SC(NC(C3=CC=C(C(N)C4=CC=CC=C4)C=C3)=O)=N2)=C1.FC(F)(C(O)=O)F
Formula C22H19N3O2S•CF3COOH M.Wt 503.5
Solubility DMF: 20 mg/mL,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg/kg, respectively.