Tafenoquine Succinate (WR 238605 (Succinate)) |
| Catalog No.GC32206 |
Tafenoquine Succinate (WR 238605 (Succinate)) (WR 238605 Succinate) is an 8-aminoquinoline.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 106635-81-8
Sample solution is provided at 25 µL, 10mM.
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Tafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1].
Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg)[1].
[1]. Marcsisin SR, et al. Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds. Malar J. 2014 Jan 3;13:2.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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