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Tat-NR2B9c TFA Catalog No.GC34828

Size Price Stock Qty
1mg
$65.00
In stock
5mg
$167.00
In stock
10mg
$260.00
In stock
25mg
$510.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1834571-04-8 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES OC(C(F)(F)F)=O.[YGRKKRRQRRRKLSSIESDV]
Formula C107H189F3N42O32 M.Wt 2632.9
Solubility H2O : ≥ 50 mg/mL (18.99 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Tat-NR2B9c (TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy[2]. EC50: 6.7 nM (PSD-95d2), 670 nM (PSD-95d1)[1]p38[2]

[1]. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15. [2]. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009.