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TAT

Catalog No.GC34401

TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide.

Products are for research use only. Not for human use. We do not sell to patients.

TAT Chemical Structure

Cas No.: 191936-91-1

Size Price Stock Qty
1mg
$110.00
In stock
5mg
$441.00
In stock
10mg
$745.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

TAT (YGRKKRRQRRR) is a HIV-1 virus-encoded Tat peptide, which can increase the yields and the solubility of heterologous proteins.

The Tat core domain contains the sequence 'YGRKKRRQRRR' and it has been demonstrated that Tat peptide fusions can increase the yields and solubility of heterologous proteins. The Tat peptide promotes the soluble expression of the membrane protein hLSECtin-CRD in E. coli without losing bioactivity and the protein expression level is not influenced compared with Tat-free proteins[1].

[1]. Dong G, et al. Tat peptide-mediated soluble expression of the membrane protein LSECtin-CRD in Escherichia coli. PLoS One. 2013 Dec 16;8(12):e83579.

Chemical Properties

Cas No. 191936-91-1 SDF
Canonical SMILES Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
Formula C64H119N33O13 M.Wt 1558.85
Solubility Soluble in Water Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.6415 mL 3.2075 mL 6.415 mL
5 mM 0.1283 mL 0.6415 mL 1.283 mL
10 mM 0.0641 mL 0.3207 mL 0.6415 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 20 reference(s) in Google Scholar.)

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