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Telratolimod (MEDI 9197) (Synonyms: MEDI9197, 3M-052)

Catalog No.GC33076

Telratolimod (MEDI 9197) (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

Products are for research use only. Not for human use. We do not sell to patients.

Telratolimod (MEDI 9197) Chemical Structure

Cas No.: 1359993-59-1

Size Price Stock Qty
10mM (in 1mL DMSO)
$411.00
In stock
5mg
$315.00
In stock
10mg
$525.00
In stock
25mg
$1,050.00
In stock
50mg
$1,470.00
In stock
100mg
$2,310.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Product Documents

Quality Control & SDS

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Background

Telratolimod is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1].

Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors[1].

[1]. Zhao BG, et al. Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors. J Immunother Cancer. 2014 May 13;2:12.

Chemical Properties

Cas No. 1359993-59-1 SDF
Synonyms MEDI9197, 3M-052
Canonical SMILES NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3OCCCCNC(CCCCCCCCCCCCCCCCC)=O
Formula C36H59N5O2 M.Wt 593.89
Solubility DMSO : 5 mg/mL (8.42 mM);Water : < 0.1 mg/mL (insoluble) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.6838 mL 8.4191 mL 16.8381 mL
5 mM 0.3368 mL 1.6838 mL 3.3676 mL
10 mM 0.1684 mL 0.8419 mL 1.6838 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for Telratolimod (MEDI 9197)

Average Rating: 5 ★★★★★ (Based on Reviews and 4 reference(s) in Google Scholar.)

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