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Tertiapin Q (trifluoroacetate salt) (Synonyms: TPN(M13Q), TPNQ)

Catalog No.GC52354

A peptide derivative of tertiapin

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Tertiapin Q (trifluoroacetate salt) Chemical Structure

Size Price Stock Qty
500 μg
$307.00
In stock
1 mg
$582.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Tertiapin Q is a peptide derivative of the honeybee venom peptide and inhibitor of inwardly rectifying potassium (Kir) channels, tertiapin.1 It inhibits heteromultimeric potassium channels composed of G protein-activated inward rectifier potassium channel 1 (GIRK1) and GIRK4, also known as Kir3.1 and Kir3.4, respectively, as well as the inward-rectifier potassium channel 1 (Kir1.1; Kis = 13.3 and 1.3 nM, respectively).2 Tertiapin Q inhibits voltage-stimulated hyperpolarization and increases action potential duration in mouse dorsal root ganglion neurons in a concentration-dependent manner.3 It inhibits BK-type potassium channels in Xenopus oocytes expressing the human BK channel α subunit (IC50 = 5.8 nM).

1.Jin, W., Klem, A.M., Lewis, J.H., et al.Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-QBiochemistry38(43)14294-14301(1999) 2.Jin, W., and Lu, Z.Synthesis of a stable form of tertiapin: A high-affinity inhibitor for inward-rectifier K+ channelsBiochemistry38(43)14286-14293(1999) 3.Kanjhan, R., Coulson, E.J., Adams, D.J., et al.Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent mannerJ. Pharmacol. Exp. Ther.314(3)1353-1361(2005)

Chemical Properties

Cas No. SDF Download SDF
Synonyms TPN(M13Q), TPNQ
Canonical SMILES O=C([C@H]1NC([C@@H](NC([C@@H](NC([C@@]2([H])N(CCC2)C([C@](NC([C@](NC([C@](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC3=O)CCCCN)=O)CCCCN)=O)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CCCCN)=O)=O)=O)NC([C@@H](NC([C@H](CSSC1)NC([C@H](CC(C)C)NC([C@@H](N)C)=O)=O)=O)CC(N)=O)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)([H])[C@@H](C)CC)=O)([H])[C@@H](C)CC)=O)=O)CC4=CN=CN4)=O)CCC(N)=O)=O)N[C@H]3CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O
Formula C106H175N35O24S4 ? XCF3COOH M.Wt 2452
Solubility Water: soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.4078 mL 2.0392 mL 4.0783 mL
5 mM 0.0816 mL 0.4078 mL 0.8157 mL
10 mM 0.0408 mL 0.2039 mL 0.4078 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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