tetranor-PGEM (Synonyms: tetranor-Prostaglandin E Metabolite) |
| Catalog No.GC45026 |
tetranor-PGEM is a metabolite of prostaglandin E2 (PEG2) as a biomarker of inflammation and cancer including advanced colorectal neoplasia, ovarian cancer, prostate cancer and so on.
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Cas No.: 24769-56-0
Sample solution is provided at 25 µL, 10mM.
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tetranor-PGEM is the major urinary metabolite of PGE1 and PGE2, and is used as a marker of PGE2 biosynthesis.[1],[2] About 15% of an infused dose of PGE2 appears as this metabolite in the urine of humans. Normal healthy males excrete 7-40 µg of tetranor-PGEM over a 24-hour period.[1]
Reference:
[1]. Hamberg, M. Inhibition of prostaglandin synthesis in man. Biochemical and Biophysical Research Communications 49, 720-726 (1972).
[2]. Honda, H., Fukawa, K., and Sawabe, T. Influence of adjuvant arthritis on main urinary metabolites of prostaglandin F and E rats. Prostaglandins 19, 259-269 (1980).
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