TFEB activator 1 (Synonyms: GO-Y019, TFEB Activator 1) |
| Catalog No.GC39530 |
A synthetic curcuminoid and activator of TFEB
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 39777-61-2
Sample solution is provided at 25 µL, 10mM.
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TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment[1].
[1]. Song JX, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016 Aug 2;12(8):1372-89.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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