|Thiocolchicine Catalog No.GC45039|
Sample solution is provided at 25 µL, 10mM.
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|Cas No.||2730-71-4||SDF||Download SDF|
|Solubility||Soluble in DMSO||Storage||Store at -20°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of colchicine . It inhibits binding of colchicine to tubulin (Ki = 0.7 µM in a radioligand binding assay). Thiocolchicine inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM).