Thiocolchicine (Synonyms: NSC 186301) |
| Catalog No.GC45039 |
Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 μM) and a derivative of colchicine.
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Cas No.: 2730-71-4
Sample solution is provided at 25 µL, 10mM.
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Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of colchicine . It inhibits binding of colchicine to tubulin (Ki = 0.7 µM in a radioligand binding assay). Thiocolchicine inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM).
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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