Thioquinapiperifil dihydrochloride (Synonyms: KF31327) |
| Catalog No.GC61943 |
Thioquinapiperifil dihydrochloride (KF31327), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study.
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Cas No.: 204077-66-7
Sample solution is provided at 25 µL, 10mM.
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Thioquinapiperifil dihydrochloride (KF31327), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2].
Thioquinapiperifil can be found in dietary supplements[1].Thioquinapiperifil dihydrochloride (KF31327) (0.1-10 µM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 µM of Thioquinapiperifil dihydrochloride (KF31327) are required to inhibit platelet aggregation[2].Thioquinapiperifil dihydrochloride (KF31327) and shows significant increase in cyclic GMP at 10 µM. After 5 min incubation, the mean cyclic GMP levels of Thioquinapiperifil dihydrochloride (KF31327)-treated cells is 0.95±0.17 pmol/108 cells[2].
References:
[1]. Nahoko Uchiyama, et al. Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement. Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1331-4.
[2]. R Hirose, et al. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur J Pharmacol. 2001 Nov 9;431(1):17-24.
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