Home>>Signaling Pathways>> Proteases>> Thrombin>>Thrombin inhibitor 1
Thrombin inhibitor 1 Catalog No.GC32639

Size Price Stock Qty
1mg
$1,526.00
In stock
5mg
$3,383.00
In stock
10mg
$5,874.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 855998-46-8 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES C[C@H](C1=CC(Cl)=CC=C1)NC(CC2=C(Cl)C=CC(NCC(F)(C3=CC=CC=N3=O)F)=N2=O)=O
Formula C22H20Cl2F2N4O3 M.Wt 497.32
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Thrombin inhibitor 1 is a potent thrombin inhibitor (Ki=0.66 nM, 2xaPTT=0.43 μM).

Thrombin inhibitor 1 (Compound 4) is binds in the active site of thrombin with Ki of 0.66 nM, 2xaPTT=0.43 uM). Thrombin inhibitor 1 (Compound 4) is evaluated for its thrombin inhibitory potency and its functional ability to double the activated partial thromboplastin time (2xaPTT) in human plasma with a 2xaPTT of 0.43 μM[1].

[1]. Nantermet PG, et al. P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2771-5.