Home>>Signaling Pathways>> Others>>Tie2 kinase inhibitor

Tie2 kinase inhibitor (Synonyms: Tunica Interna Endothelial Cell Kinase 2 Inhibitor)

Catalog No.GC14898

Tie2 kinase inhibitor (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM. Tie2 kinase inhibitor has anti-cancer activity.

Products are for research use only. Not for human use. We do not sell to patients.

Tie2 kinase inhibitor Chemical Structure

Cas No.: 948557-43-5

Size Price Stock Qty
10mM (in 1mL DMSO)
In stock
In stock
In stock
In stock

Tel:(909) 407-4943 Email: sales@glpbio.com

Customer Reviews

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

Tie2 kinase inhibitor is a reversible and selective inhibitor of Tie2 with an IC50 of 250 nM [1].

Tie2 kinase inhibitor (2 µM) clearly decreased phosphorylation of AKT in TDEC IR- and in TDEC IR+ (TDEC obtained from irradiated GSC). Tie2 kinase inhibitor (2 µM) induced a significant decrease in the number of CD31+ TDEC obtained from non-irradiated SRA5 and SRB1 GSC, but not from non-irradiated SRC3 GSC [2]. Treatment with Tie2 kinase inhibitor (0-3 µg/ml) resulted in significant reduction of both invadopodia and colony formation in fibrin-fibronectin embedded B16F1 cells [3]. ​SRSF1-WT transfected cells showed more sensitivity to Tie2 kinase inhibition, and SRSF1-Y19F cells showed resistant to the Tie2 kinase inhibitor compared to the empty vector-transfected cells. Tie2 kinase inhibitor showed more intensive effect on the colony-forming properties of SRSF1-WT cells [4]. Tie2 kinase inhibitor(5 µM)treatment decreased P-Akt of primary rat PitNET cells [5].

After subcutaneous implantation of the plugs containing the cells, mice were injected twice daily with the vehicle or the Tie2 kinase inhibitor for 14 days, plugs with TDEC IR+ with Tie2 kinase inhibitor had significantly fewer functional blood vessels than plugs with TDEC IR+ control. The number of hCD31+ vessels was also lower in plugs with TDEC IR+ with Tie2 kinase inhibitor compared to plugs with TDEC IR+ control [2].

[1]. Semones M, Feng Y, Johnson N, et al. Pyridinylimidazole inhibitors of Tie2 kinase[J]. Bioorganic & medicinal chemistry letters, 2007, 17(17): 4756-4760.
[2]. Deshors P, Toulas C, Arnauduc F, et al. Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway[J]. Cell death & disease, 2019, 10(11): 1-15.
[3]. Knowles L M, Malik G, Pilch J. Plasma fibronectin promotes tumor cell survival and invasion through regulation of Tie2[J]. Journal of Cancer, 2013, 4(5): 383.
[4]. Xu L, Zhang H, Mei M, et al. Phosphorylation of serine/arginine‐rich splicing factor 1 at tyrosine 19 promotes cell proliferation in pediatric acute lymphoblastic leukemia[J]. Cancer science, 2018, 109(12): 3805-3815.
[5]. Karabid N M, Wiedemann T, Gulde S, et al. Angpt2/Tie2 autostimulatory loop controls tumorigenesis[J]. EMBO molecular medicine, 2022, 14(5): e14364.


Review for Tie2 kinase inhibitor

Average Rating: 5 ★★★★★ (Based on Reviews and 3 reference(s) in Google Scholar.)

5 Star
4 Star
3 Star
2 Star
1 Star
Review for Tie2 kinase inhibitor

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.