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Timepidium bromide (Sesden)

Catalog No.GC32666

Timepidium bromide (Sesden) (Sesden; SA504) is an anticholinergic agent.

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Timepidium bromide (Sesden) Chemical Structure

Cas No.: 35035-05-3

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1mg
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10mg
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20mg
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Sample solution is provided at 25 µL, 10mM.

Description of Timepidium bromide (Sesden)

Timepidium bromide (Sesden; SA504) is an anticholinergic agent.

Effects of Timepidium bromide (TB), acetylcholine (ACh) and neostigmine (Neost) on gastric and duodenal blood flow distribution are studied by the use of 131I-labeled macroaggregated human serum albumin (MAA) in rabbits. In normal rabbits, gastric blood flow is found to be uneven in various regions of the stomach: anterior corpus (50% of total gastric blood flow) greater than posterior corpus (40%) greater than pyloric antrum (7%). Intravenous administration of Timepidium bromide (200 μg/kg) to normal rabbits produces a slight increase in total gastric blood flow, but the increase in the mucosal layer of the pyloric antrum is considerable[1].

[1]. Naito K, et al. Effect of timepidium bromide, an anticholinergic agent, on gastric and duodenal blood flow distribution in rabbits. Jpn J Pharmacol. 1982 Feb;32(1):73-80.

Protocol of Timepidium bromide (Sesden)

Animal experiment:

Rabbits[1]Timepidium bromide (200 μg/kg) is injected into the femoral vein 5 min prior to 131I-MAA. To evaluate the effects of Timepidium bromide on gastric and duodenal blood flow in cholinergic drug-treated animals, Timepidium bromide is administered in a dose of 200 μg/kg through the femoral vein 3 min before ACh or 5 min after Neost. 131I-MAA is given into the left ventricle of the animals 2 min after ACh and 10 min after Neost.

References:

[1]. Naito K, et al. Effect of timepidium bromide, an anticholinergic agent, on gastric and duodenal blood flow distribution in rabbits. Jpn J Pharmacol. 1982 Feb;32(1):73-80.

Chemical Properties of Timepidium bromide (Sesden)

Cas No. 35035-05-3 SDF
Canonical SMILES C[N+]1(C)C/C(CC(OC)C1)=C(C2=CC=CS2)\C3=CC=CS3.[Br-]
Formula C17H22BrNOS2 M.Wt 400.4
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Timepidium bromide (Sesden)

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1 mg 5 mg 10 mg
1 mM 2.4975 mL 12.4875 mL 24.975 mL
5 mM 0.4995 mL 2.4975 mL 4.995 mL
10 mM 0.2498 mL 1.2488 mL 2.4975 mL
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In vivo Formulation Calculator (Clear solution) of Timepidium bromide (Sesden)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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