Tiopinac (RS 40974) |
| Catalog No.GC31821 |
Tiopinac (RS 40974) (RS 40974), a dibenzthiepin, is an orally active and highly potent anti-inflammatory and anti-pyretic agent.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 61220-69-7
Sample solution is provided at 25 µL, 10mM.
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Tiopinac is a highly potent anti-inflammatory, analgesic and anti-pyretic agent.
Tiopinac (0.03-110 mg/kg) has 40 times the antiphlogistic potency of phenylbutazone. The dose required to reduce paw swelling by 30% is approximately 0.5 mg/kg. Tiopinac does not elicit overt side effects at the 20 mg/kg/day dose. Tiopinac causes a dose-related reversal of the decreases body weight caused by the adjuvant disease, the weight of those rats receiving 0.135 and 0.4 mg/kg/day being significantly greater than that of the positive controls. Tiopinac (0.3-30 mg/kg) is highly potent in inhibiting the pain evoked in the yeastinflamed hind paw of the rat[1].
[1]. Rooks WH 2nd, et al. The anti-inflammatory and analgesic profile of 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid (tiopinac). Agents Actions. 1980 Jun;10(3):266-73.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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