Tirabrutinib hydrochloride (ONO-4059 (hydrochloride)) (Synonyms: GS-4059, ONO-WG-307) |
| Catalog No.GC34097 |
Tirabrutinib (ONO-4059) hydrochloride is an orally active Bruton's Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM.
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Cas No.: 1439901-97-9
Sample solution is provided at 25 µL, 10mM.
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Tirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.
[1]. Akintunde Akinleye et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol, 2013, 6: 59. [2]. Harriet S et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood 2016, 127:411-419.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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