Tumulosic Acid (Synonyms: Polyporenic Acid B) |
| Catalog No.GC49835 |
Tumulosic Acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 508-24-7
Sample solution is provided at 25 µL, 10mM.
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Tumulosic acid is a triterpene that has been found in Poria cocos and has diverse biological activities.1,2,3,4 It inhibits DNA topoisomerase I and II by 83.3 and 75.5%, respectively, when used at a concentration of 100 µM.1 Tumulosic acid also inhibits kallikrein 5 and trypsin but not kallikrein 7 or chymotrypsin C (IC50s = 14.8, 45.3, >100, and >100 µM for the human enzymes, respectively).2 It inhibits LPS-induced nitric oxide (NO) production (IC50 = 42.5 µM) and activator protein 1 (AP-1) transcriptional activity in RAW 264.7 macrophages.3 Tumulosic acid (30 µg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate in mice.4
1.Gao, L., Xu, M.-L., Lee, C.-S., et al.Cytotoxicity and DNA topoisomerases inhibitory activity of constituents from the sclerotium of Poria cocosArch. Pharm. Res.27(8)829-833(2004) 2.Matsubara, Y., Matsumoto, T., Koseki, J., et al.Inhibition of human kallikrein 5 protease by triterpenoids from natural sourcesMolecules22(11)1829(2017) 3.Cai, T.-G., and Cai, Y.Triterpenes from the fungus Poria cocos and their inhibitory activity on nitric oxide production in mouse macrophages via blockade of activating protein-1 pathwayChem. Biodivers.8(11)2135-2143(2011) 4.Nukaya, H., Yamashiro, H., Fukazawa, H., et al.Isolation of inhibitors of TPA-induce mouse ear edema from Hoelen Poria cocosChem. Pharm. Bull. (Tokyo)44(4)847-849(1996)
| Cas No. | 508-24-7 | SDF | |
| Synonyms | Polyporenic Acid B | ||
| Canonical SMILES | C[C@]12[C@@]([C@]([C@@H](CCC(C(C)C)=C)C(O)=O)([H])[C@@H](C1)O)(CCC3=C2CC[C@]4([H])[C@@]3(CC[C@@H](C4(C)C)O)C)C | ||
| Formula | C31H50O4 | M.Wt | 486.7 |
| Solubility | DMSO: 10 mM | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0547 mL | 10.2733 mL | 20.5465 mL |
| 5 mM | 0.4109 mL | 2.0547 mL | 4.1093 mL |
| 10 mM | 0.2055 mL | 1.0273 mL | 2.0547 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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