UK-371804 HCl |
| Catalog No.GC26017 |
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 256476-36-5
Sample solution is provided at 25 µL, 10mM.
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UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
In Vitro, UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM)[1].
In Vivo, in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters[1].
[1] Fish PV, et al. J Med Chem. 2007, 50(10):2341-51.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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