Urocortin II (human) (trifluoroacetate salt) |
| Catalog No.GC18231 |
Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 398001-88-2
Sample solution is provided at 25 µL, 10mM.
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Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I. Human urocortin II shares 34, 43, and 37-40% sequence homology with rat and human CRF, human urocortin , and human urocortin III. Urocortin II increases cell shortening and accelerates relaxation of rabbit ventricular myocytes in a time- and concentration-dependent manner. In vivo, urocortin reduces arterial blood pressure in normotensive and spontaneously hypertensive rats via peripheral CRF2 receptor agonism. It induces dose-dependent tachycardia and hypotension in rats when administered at doses of 3 and 30 pmol/kg. Urocortin (10 and 20 μg/kg) also reduces the visceral pain response to colorectal distension in conscious rats and delays gastric emptying in mice.
References:
[1]. Ad?o, R., Santos-Ribeiro, D., Rademaker, M.T., et al. Urocortin 2 in cardiovascular health and disease Drug Discov. Today 20(7), 906-914 (2015).
[2]. Gardiner, S.M., March, J.E., Kemp, P.A., et al. Regional hemodynamic actions of selective corticotropin-releasing factor type 2 receptor ligands in conscious rats J. Pharmacol. Exp. Ther. 312(1), 53-60 (2005).
[3]. Million, M., Wang, L., Wang, Y., et al. CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1/2 phosphorylation in rats Gut 55(2), 172-181 (2006).
| Cas No. | 398001-88-2 | SDF | |
| Chemical Name | N/A | ||
| Canonical SMILES | N/A | ||
| Formula | C194H339N63O54S.XCF3COOH | M.Wt | 4450.2 |
| Solubility | Formic Acid: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.2247 mL | 1.1235 mL | 2.2471 mL |
| 5 mM | 0.0449 mL | 0.2247 mL | 0.4494 mL |
| 10 mM | 0.0225 mL | 0.1124 mL | 0.2247 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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