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Vapendavir-d5 (Synonyms: BTA798-d5)

Catalog No.GC48242

A neuropeptide with diverse biological activities

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Vapendavir-d5 Chemical Structure

Cas No.: 2738376-73-1

Size Price Stock Qty
500 μg
$170.00
In stock
1 mg
$321.00
In stock
5 mg
$1,442.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description of Vapendavir-d5

Vapendavir-d5 is intended for use as an internal standard for the quantification of vapendavir by GC- or LC-MS. Vapendavir is a capsid-binding antiviral agent.1,2 It binds to a pocket in the human rhinovirus (HRV) strain HRV2 VP1 capsid protein and inhibits the cytopathic effects of HRV2 and HRV14 in HeLa Ohio cells (EC50s = 1 and 5 ng/ml, respectively), as well as in a panel of 39 HRV clinical isolates (median EC50 = 7.3 ng/ml).1 Vapendavir inhibits replication in a panel of 21 enterovirus 71 (EV71) isolates with an average EC50 value of 0.7 μM.2

1.Feil, S.C., Hamilton, S., Krippner, G.Y., et al.An orally available 3-ethoxybenzisoxazole capsid binder with clinical activity against human rhinovirusACS Med. Chem. Lett.3(4)303-307(2012) 2.Tijsma, A., Franco, D., Tucker, S., et al.The capsid binder vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replicationAntimicrob. Agents Chemother.58(11)6990-6992(2014)

Chemical Properties of Vapendavir-d5

Cas No. 2738376-73-1 SDF
Synonyms BTA798-d5
Canonical SMILES CC1=CC=C(N=N1)N(CC2)CCC2CCOC3=CC=C(C(OC([2H])([2H])C([2H])([2H])[2H])=NO4)C4=C3
Formula C21H21D5N4O3 M.Wt 387.5
Solubility DMSO: Soluble,Methanol: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Vapendavir-d5

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1 mg 5 mg 10 mg
1 mM 2.5806 mL 12.9032 mL 25.8065 mL
5 mM 0.5161 mL 2.5806 mL 5.1613 mL
10 mM 0.2581 mL 1.2903 mL 2.5806 mL
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In vivo Formulation Calculator (Clear solution) of Vapendavir-d5

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 29 reference(s) in Google Scholar.)

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