VCP 171 |
| Catalog No.GC50671 |
A positive allosteric modulator of adenosine A1 receptors
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1018830-99-3
Sample solution is provided at 25 µL, 10mM.
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Adenosine A1 receptor positive allosteric modulator (PAM) (pKB = 5.65, binding cooperativity with NECA 0.68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor-mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve-injury model of neuropathic pain.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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