VEGFR Tyrosine Kinase Inhibitor II (Synonyms: Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor II) |
| Catalog No.GC16062 |
VEGFR Tyrosine Kinase Inhibitor II (compound 3) is a potent angiogenesis inhibitor with IC50s of 0.02, 0.18, 0.24 7.3, and 7 μM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively.
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Cas No.: 269390-69-4
Sample solution is provided at 25 µL, 10mM.
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VEGFR tyrosine kinase inhibitor II is a pyridinyl-anthranilamide compound that inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50s = 20, 180, and 240 nM, respectively).1 It displays minimal activity against c-Src and EGFR (IC50s = 7 and 7.3 µM, respectively) and is inactive against Cdk1, c-Met, IGF-1R, and PKA (IC50s > 10 µM).1 VEGFR tyrosine kinase inhibitor II has been investigated for its potential to inhibit tumor induced angiogenesis.[1]
Reference:
[1] Furet, P., Bold, G., Hofmann, F., et al. Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching. Bioorganic & Medicinal Chemistry Letters 13(18), 2967-2971 (2003).
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